Background:
In an effort to provide consistent reporting with total IgG, and in consultation with UCI’s Institute for Immunology, the Department of Pathology will change the units for IgG subclasses from mg/L to mg/dL.
Reference intervals remain in accordance with the manufacturer’s recommendations. The adult serum reference intervals were verified in 24 adult blood donors. Pediatric ranges will also be maintained in accordance with manufacturer’s recommendations.
Test Name |
Test Code |
Previous Adult Reference Interval (mg/L) |
Updated Adult Reference Interval (mg/dL) |
Immunoglobulin IgG Subclass 1 |
IGGSUB |
3824 - 9286 mg/L |
382 - 929 mg/dL |
Immunoglobulin IgG Subclass 2 |
IGGSUB |
2418 - 7003 mg/L |
242 - 700 mg/dL |
Immunoglobulin IgG Subclass 3 |
IGGSUB |
218 - 1761 mg/L |
22 - 176 mg/dL |
Immunoglobulin IgG Subclass 4 |
IGGSUB, IGG4 |
52 - 1250 mg/L |
5 - 125 mg/dL |
Effective date: Nov. 14, 2019
Specimen requirement and testing information:
Specimen: Serum
Test methodology: Turbidimetry
Test codes: IGGSUB, IGG4
IGGSUB Minimum stability (after separation from cells):
Ambient: Unacceptable
Refrigerated: 3 days (IgG1, IgG2), 8 days (IgG3, IgG4, IgG)
Frozen: 1 month
IGG4 Minimum stability (after separation from cells):
Ambient: Unacceptable
Refrigerated: 8 days
Frozen: 1 month
Turnaround time (TAT):
STAT: N/A
Routine: 1 - 4 days
Set Up Days: M, W, F
Rejection criteria:
Samples containing particulate matter, and lipemic or hemolyzed specimens. Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers, or specimens received with insufficient amounts for testing.
A summary of all tests offered by our laboratory services can be found here: http://www.pathology.uci.edu/services/index.asp
Sincerely,
Bridgit O. Crews, PhD, DABCC
Director
Clinical Chemistry & Toxicology
Edwin S. Monuki, MD, PhD
Chair
Department of Pathology & Laboratory Medicine |